Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
                    
                        
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                    چکیده
منابع مشابه
Inter-individual variation of DNA methylation and its implications for large-scale epigenome mapping
Genomic DNA methylation profiles exhibit substantial variation within the human population, with important functional implications for gene regulation. So far little is known about the characteristics and determinants of DNA methylation variation among healthy individuals. We performed bioinformatic analysis of high-resolution methylation profiles from multiple individuals, uncovering complex p...
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The extent of variation in DNA methylation patterns in healthy individuals is not yet well documented. Identification of inter-individual epigenetic variation is important for understanding phenotypic variation and disease susceptibility. Using neutrophils from a cohort of healthy individuals, we generated base-resolution DNA methylation maps to document inter-individual epigenetic variation. W...
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Epigenetic changes play an essential role in cancer pathogenesis. It has been established by next-generation sequencing that more than 50% of the human cancers carry mutations in mechanisms involved in the organization of the chromatin and epigenetic regulations. DNA methylation is among the most common epigenetic changes in leukemia. In contrast to DNA mutations which are passively inherited f...
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Background: The annual effective dose equivalent (AEDE) due to ionizing radiation in a coaster area in Nigerian has been determined using Geiger-Muller counter. Materials and Methods: isolevels in the study area were represented by using the kriging interpolation technique on ArcGIS 10.1 software. Duncan multiple range test was performed using Statistical Package for Social Sciences (SPSS). Res...
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Epidemiological studies have reported a higher incidence of rare disorders involving imprinted genes among children conceived using assisted reproductive technology (ART), suggesting that ART procedures may be disruptive to imprinted gene methylation patterns. We examined intra- and inter-individual variation in DNA methylation at the differentially methylated regions (DMRs) of the IGF2/H19 and...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2008
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkn122